Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 8/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.38 |
| ▸ | ITGAV | P06756 | 5/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.38 |
| ▸ | MDM4 | O15151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778846 | 0.88 | KMT2A (0.36) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL6779887 | 0.84 | ITGB3 (0.46) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL6778268 | 0.83 | GPR139 (0.44) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL6775970 | 0.83 | GPR132 (0.49) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL6778973 | 0.83 | GPR139 (0.45) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL6776071 | 0.82 | GPR139 (0.39) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL7344536 | 0.81 | POLB (0.39) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL3051751 | 0.81 | GPR139 (0.44) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL6782093 | 0.81 | ITGB1 (0.41) | GPR139ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL7823171 | 0.81 | ITGB3 (0.50) | ITGB1ITGA5ITGB3ITGAVMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |