Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 9/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.39 |
| ▸ | ITGAV | P06756 | 6/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341582 | 0.90 | GPR139 (0.41) | GPR139MEN1KMT2AATM | |
| SCHEMBL6775970 | 0.88 | GPR132 (0.49) | GPR139ITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL7823171 | 0.86 | ITGB3 (0.50) | ITGB1ITGB3ITGAVITGA5MDM2 | |
| SCHEMBL3051751 | 0.86 | GPR139 (0.44) | GPR139SLC6A9SLC6A5ITGB1ITGB3 | |
| SCHEMBL6772224 | 0.85 | CTSV (0.50) | GPR139SLC6A9SLC6A5ITGB1ITGB3 | |
| SCHEMBL7838300 | 0.85 | ITGB3 (0.51) | GPR139ITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL6778268 | 0.85 | GPR139 (0.44) | GPR139ITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL7340124 | 0.85 | CA2 (0.46) | GPR139SLC6A9SLC6A5ITGB1ITGB3 | |
| SCHEMBL6779571 | 0.85 | FPR2 (0.43) | ITGB1ITGB3ITGAVITGA5MDM2 | |
| SCHEMBL7835380 | 0.84 | GPR132 (0.42) | GPR139ITGB1ITGB3ITGAVITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| US-6831199-B1 | In order to avoid bleeding side-effects when treating the conditions associated with integrin alpha v beta 3, it is beneficial to have compounds which are selective antagonists for alpha v beta 3 versus alpha IIb beta 3 | G. D. SEARLE & CO. | 2004-12-14 | — | — | US | disclosed |