Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340476 | 1.00 | ALDH1A1 (0.34) | ALDH1A1KMT2AMAPTPKMLMNA | |
| SCHEMBL7343122 | 0.84 | NAMPT (0.42) | ALDH1A1MAPTLMNAMAPK1KDM4E | |
| SCHEMBL7348218 | 0.82 | NAMPT (0.51) | KMT2AGAA | |
| SCHEMBL7345846 | 0.79 | ITGB3 (0.38) | ITGB1ITGA5 | |
| SCHEMBL7346226 | 0.78 | LMNA (0.35) | ALDH1A1KMT2AMAPTPKMLMNA | |
| SCHEMBL7338530 | 0.77 | MAPT (0.34) | ALDH1A1KMT2AMAPTLMNAMEN1 | |
| SCHEMBL7338522 | 0.77 | MAPT (0.34) | ALDH1A1KMT2AMAPTLMNAMEN1 | |
| SCHEMBL7344514 | 0.72 | ITGB3 (0.40) | ALDH1A1KMT2AMEN1ITGB1ITGA5 | |
| SCHEMBL7344509 | 0.72 | ITGB3 (0.40) | ALDH1A1KMT2AMEN1ITGB1ITGA5 | |
| SCHEMBL7343120 | 0.71 | ITGB3 (0.48) | ALDH1A1KMT2APKMMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |