Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14123262 | 0.83 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL24703554 | 0.79 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL7344009 | 0.79 | TSHR (0.46) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL667246 | 0.72 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL7643580 | 0.71 | SLC9A1 (0.58) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL5712332 | 0.70 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL23635683 | 0.70 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TP53 | |
| SCHEMBL11811656 | 0.68 | KDM4E (0.80) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL24438895 | 0.67 | ALDH1A1 (0.54) | KDM4ESMN1; SMN2ALDH1A1HSD17B10KAT2B | |
| SCHEMBL1006937 | 0.67 | CYP3A4 (0.57) | KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307094-A | ANTIHYPERTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |
| EP-0024309-A2 | Triazolopyridazine derivatives, process and intermediates for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-03-04 | — | — | EP | disclosed |