Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28974261 | 0.85 | TSHR (0.43) | TSHRKAT2BALDH1A1KDM4EKMT2A | |
| SCHEMBL11655337 | 0.81 | TSHR (0.52) | TSHRKAT2BALDH1A1KDM4EKMT2A | |
| SCHEMBL24682696 | 0.81 | APEX1 (0.61) | TSHRKAT2BALDH1A1KDM4EKMT2A | |
| SCHEMBL7340852 | 0.79 | KDM4E (0.52) | TSHRKAT2BALDH1A1KDM4EKMT2A | |
| SCHEMBL10329440 | 0.74 | APEX1 (0.53) | TSHRKAT2BALDH1A1KDM4EMAPT | |
| SCHEMBL6928567 | 0.73 | SLC9A1 (0.49) | TSHRKAT2BALDH1A1KDM4EKMT2A | |
| SCHEMBL7337761 | 0.71 | SMN1; SMN2 (0.41) | TSHRKAT2BALDH1A1KDM4EHTT | |
| SCHEMBL16004374 | 0.69 | NPSR1 (0.47) | TSHRKAT2BALDH1A1KDM4EKMT2A | |
| SCHEMBL16004373 | 0.69 | NPSR1 (0.47) | TSHRKAT2BALDH1A1KDM4EKMT2A | |
| SCHEMBL5590841 | 0.68 | SMN1; SMN2 (0.49) | TSHRKAT2BALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307094-A | ANTIHYPERTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |
| EP-0024309-A2 | Triazolopyridazine derivatives, process and intermediates for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-03-04 | — | — | EP | disclosed |