SCHEMBL7340855

SCHEMBL7340855

CCOC(=O)C(Cc1cccnc1)NC(=O)CNC(=O)c1cccc(NC(N)=O)c1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.45
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.43
NPC1 O15118 1/20 0.43
HPGD P15428 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
GPR132 Q9UNW8 8/20 0.42
CMKLR2 P46091 1/20 0.42
CMKLR1 Q99788 1/20 0.42
TP53 P04637 1/20 0.41
NAMPT P43490 1/20 0.41
KMT2A Q03164 1/20 0.41
NLRP3 Q96P20 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6773680 0.93 ALDH1A1 (0.44) TSHRALDH1A1MAPTNPC1HPGD
SCHEMBL7835626 0.90 TSHR (0.48) TSHRALDH1A1MAPTSMN1; SMN2GPR132
SCHEMBL6779491 0.88 TSHR (0.55) TSHRMAPTNPC1SMN1; SMN2NAMPT
SCHEMBL7834945 0.88 GPR132 (0.52) TSHRGPR132CMKLR2CMKLR1
SCHEMBL7338811 0.88 GPR132 (0.46) TSHRALDH1A1GPR132CMKLR2CMKLR1
SCHEMBL7836894 0.88 NAMPT (0.59) TSHRNPC1SMN1; SMN2NAMPTKMT2A
SCHEMBL7345153 0.88 TSHR (0.46) TSHRSMN1; SMN2GPR132CMKLR2CMKLR1
SCHEMBL6779302 0.87 GPR132 (0.44) ALDH1A1GPR132CMKLR2CMKLR1TP53
SCHEMBL7835677 0.87 GPR132 (0.42) ALDH1A1MAPTGPR132CMKLR2CMKLR1
SCHEMBL7836417 0.86 GPR139 (0.49) TSHRALDH1A1GPR132CMKLR2CMKLR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0850221-B1 META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS SEARLE & CO (US) 2001-07-18 EP claimed
EP-0850221-A1 META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS G.D. SEARLE & CO. (US) 1998-07-01 EP claimed
WO-1997008145-A1 META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS G.D. SEARLE & CO. (US) 1997-03-06 WO claimed
EP-0850221-B1 META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS SEARLE & CO (US) 2001-07-18 EP disclosed
US-6028223-A AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS G. D. SEARLE & CO. (US) 2000-02-22 US disclosed