Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 6/20 | 0.32 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346234 | 0.89 | KMT2A (0.34) | ITGB3ITGA2BF10PRSS1MAPT | |
| SCHEMBL7375174 | 0.82 | ITGB3 (0.33) | ITGB3ITGA2BITGAVITGB6 | |
| SCHEMBL7340934 | 0.81 | ITGB3 (0.37) | ITGB3ITGA2BF10PRSS1SMN1; SMN2 | |
| SCHEMBL7336943 | 0.80 | NPC1 (0.33) | ITGB3ITGA2BSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL7343452 | 0.76 | ITGB3 (0.37) | ITGB3ITGA2BF10PRSS1SMN1; SMN2 | |
| SCHEMBL7348225 | 0.75 | ITGB3 (0.38) | ITGB3ITGA2BF10PRSS1SMN1; SMN2 | |
| SCHEMBL7341549 | 0.75 | — | — | |
| SCHEMBL7348823 | 0.75 | ITGB3 (0.37) | ITGB3ITGA2BF10PRSS1SMN1; SMN2 | |
| SCHEMBL7347196 | 0.74 | HTT (0.37) | ITGB3ITGA2BF10PRSS1SMN1; SMN2 | |
| SCHEMBL7341117 | 0.74 | ITGB3 (0.39) | ITGB3ITGA2BF10PRSS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |