Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 3/20 | 0.48 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.46 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.46 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.46 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.46 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.46 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.46 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 7/20 | 0.55 |
| ▸ | KLK1 | P06870 | 6/20 | 0.55 |
| ▸ | PLG | P00747 | 5/20 | 0.55 |
| ▸ | PLAT | P00750 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338981 | 0.93 | PLAU (0.63) | PLAUKLK1PLGPLATKMT2A | |
| SCHEMBL7338984 | 0.93 | PLAU (0.63) | PLAUKLK1PLGPLATKMT2A | |
| SCHEMBL7338147 | 0.90 | FTO (0.55) | FTOPLAUKLK1PLGPLAT | |
| SCHEMBL7342372 | 0.87 | FTO (0.53) | FTOPLAUKLK1PLGPLAT | |
| SCHEMBL7330202 | 0.83 | TNFRSF1A (0.58) | KMT2AALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL10922456 | 0.83 | FTO (0.74) | FTOPLAUKLK1PLGPLAT | |
| SCHEMBL10938260 | 0.82 | FTO (0.57) | FTOPLAUKLK1PLGPLAT | |
| SCHEMBL3362022 | 0.82 | KMT2A (0.68) | PLAUKLK1PLGPLATKMT2A | |
| SCHEMBL3362024 | 0.82 | KMT2A (0.68) | PLAUKLK1PLGPLATKMT2A | |
| SCHEMBL7347800 | 0.82 | PLAU (0.51) | FTOPLAUKLK1PLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048433-B1 | NOVEL AMIDINE COMPOUNDS, PROCESS FOR PRODUCING SAME AND ANTI-COMPLEMENT AGENT COMPRISING THEM | TORII & CO., LTD. (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4532255-A | Amidine compounds and anticomplement agent comprising same | TORII & CO., LTD. (JP) | 1985-07-30 | — | — | US | disclosed |
| US-4454338-A | 6-AMIDINO-2-NATHTHYL-4-GUANIDINOBENZOATE | TORII & CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
| EP-0048433-A2 | Novel amidine compounds, process for producing same and anti-complement agent comprising them | TORII & CO., LTD. (JP) | 1982-03-31 | — | — | EP | disclosed |