Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349477 | 0.79 | KDM4E (0.51) | PARP1DAOMAPTKDM4ELMNA | |
| SCHEMBL7341890 | 0.77 | PARP1 (0.44) | PARP1DAOMAPTKDM4EATAD2 | |
| SCHEMBL7338498 | 0.74 | PARP1 (0.47) | PARP1DAOMAPTKDM4EATAD2 | |
| SCHEMBL30615116 | 0.68 | ALOX15 (0.48) | MAPTKDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL6784749 | 0.68 | PARP1 (0.51) | PARP1DAOMAPTKDM4EATAD2 | |
| SCHEMBL24312059 | 0.65 | ATAD2 (0.64) | PARP1DAOMAPTKDM4EATAD2 | |
| SCHEMBL16463537 | 0.64 | DAO (0.62) | PARP1DAOMAPTKDM4EATAD2 | |
| Oxalic Acid SCHEMBL1649530 | 0.64 | KDM4E (0.73) | MAPTKDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL217044 | 0.63 | MAPT (1.00) | MAPTKDM4ESMN1; SMN2LMNAMEN1 | |
| Bicarbonate SCHEMBL7036174 | 0.62 | KDM4E (0.52) | PARP1MAPTKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |