Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 6/20 | 0.43 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341893 | 0.79 | PARP1 (0.43) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL7345844 | 0.78 | ALDH1A1 (0.55) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL7337387 | 0.75 | ALDH1A1 (0.51) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL7349473 | 0.74 | ALDH1A1 (0.50) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL7341095 | 0.74 | DAO (0.61) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL7339379 | 0.74 | PARP1 (0.57) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL7342194 | 0.74 | ALDH1A1 (0.65) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL4459257 | 0.73 | HSD17B10 (0.73) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL7339595 | 0.71 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL6793982 | 0.70 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |