Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 3/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | CPA1 | P15085 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | IL1RN | P18510 | 1/20 | 0.51 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.51 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.51 |
| ▸ | TACR2 | P21452 | 3/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341943 | 0.94 | CTSS (0.53) | RENPLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7342769 | 0.91 | PLG (0.64) | RENPLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7340564 | 0.91 | CTSS (0.52) | RENPLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7345744 | 0.90 | REN (0.57) | RENPLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7337028 | 0.88 | PSMB1 (0.58) | MMEACECPA1ACE2IL1RN | |
| SCHEMBL7338161 | 0.88 | CTSS (0.51) | RENPLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7346203 | 0.88 | CTSS (0.53) | RENPLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7337461 | 0.88 | MMP8 (0.57) | RENCTSSCTSKMMEACE | |
| SCHEMBL7340618 | 0.87 | CTSS (0.50) | RENPLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7335394 | 0.87 | TACR2 (0.62) | CTSSTACR2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | claimed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |