Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 1/20 | 0.49 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345844 | 0.86 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL7337387 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL7338765 | 0.82 | KDM4E (0.51) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL7349473 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL3601642 | 0.79 | HSD17B10 (1.00) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL7341095 | 0.79 | DAO (0.61) | ALDH1A1KDM4ELMNAHSD17B10PARP1 | |
| SCHEMBL29364659 | 0.78 | KDM4E (0.59) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| SCHEMBL31394 | 0.78 | KDM4E (0.59) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| Hydrochloric Acid SCHEMBL5027809 | 0.77 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| Fluoride SCHEMBL29664116 | 0.77 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |