Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337387 | 0.88 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAHSD17B10PARP1 | |
| SCHEMBL7349473 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4ELMNAHSD17B10PARP1 | |
| SCHEMBL7342194 | 0.86 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAHSD17B10PARP1 | |
| SCHEMBL7338765 | 0.81 | KDM4E (0.51) | ALDH1A1KDM4ELMNAHSD17B10PARP1 | |
| SCHEMBL7348155 | 0.80 | DAO (0.44) | KDM4EPARP1TDP1 | |
| SCHEMBL11095481 | 0.80 | PARP1 (0.54) | ALDH1A1KDM4ELMNAPARP1TDP1 | |
| SCHEMBL4459257 | 0.80 | HSD17B10 (0.73) | ALDH1A1KDM4ELMNAHSD17B10PARP1 | |
| SCHEMBL29390425 | 0.79 | DAO (0.58) | ALDH1A1KDM4EHSD17B10BRD4GAA | |
| SCHEMBL29537 | 0.79 | DAO (0.58) | ALDH1A1KDM4EHSD17B10BRD4GAA | |
| SCHEMBL7349477 | 0.78 | KDM4E (0.51) | ALDH1A1KDM4ELMNAHSD17B10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |