Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345190 | 0.77 | GRM2 (0.43) | GRM2PTGS1PTGS2MAPK14GRM5 | |
| Hydrochloric Acid SCHEMBL7348587 | 0.72 | PDE3B (0.48) | PDE2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11083302 | 0.70 | PTGS1 (0.57) | GRM2PTGS1PTGS2MAPK14FLT3 | |
| SCHEMBL11091670 | 0.70 | PTGS1 (0.57) | GRM2PTGS1PTGS2MAPK14FLT3 | |
| SCHEMBL5849861 | 0.67 | ALDH1A1 (0.46) | PTGS1PTGS2 | |
| SCHEMBL11086876 | 0.67 | PTGS1 (0.44) | GRM2PTGS1PTGS2RIPK3MAPK14 | |
| SCHEMBL22510450 | 0.65 | — | — | |
| SCHEMBL1430224 | 0.64 | — | — | |
| SCHEMBL34460999 | 0.63 | CLK4 (0.52) | GRM2PTGS1PTGS2MAPK14GRM5 | |
| SCHEMBL3223866 | 0.62 | GRM2 (0.38) | GRM2HTTMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |
| EP-0329691-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES. | SCHERING AG (DE) | 1989-08-30 | — | — | EP | disclosed |
| WO-1988003531-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-05-19 | — | — | WO | disclosed |
| US-4737511-A | Cardiotonic imidazolylphenylpyrrol-2-ones | SCHERING A.G. (DE) | 1988-04-12 | — | — | US | disclosed |