Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342203 | 0.77 | GRM2 (0.40) | GRM2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL11091670 | 0.74 | PTGS1 (0.57) | GRM2PTGS1FLT3CLK4MAPK14 | |
| SCHEMBL11083302 | 0.74 | PTGS1 (0.57) | GRM2PTGS1FLT3CLK4MAPK14 | |
| SCHEMBL7344047 | 0.71 | PDE3B (0.54) | — | |
| SCHEMBL7341161 | 0.71 | PDE3B (0.54) | — | |
| SCHEMBL11086876 | 0.70 | PTGS1 (0.44) | GRM2PTGS1FLT3MAPK14PTGS2 | |
| SCHEMBL18593200 | 0.68 | JAK2 (0.31) | — | |
| SCHEMBL34460999 | 0.66 | CLK4 (0.52) | GRM2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL29984992 | 0.64 | CLK4 (0.73) | GRM2DAPK3NTRK1PIM1FLT3 | |
| SCHEMBL28223904 | 0.64 | PIK3CD (0.64) | GRM2NTRK1PIM1FLT3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |
| EP-0329691-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES. | SCHERING AG (DE) | 1989-08-30 | — | — | EP | disclosed |
| WO-1988003531-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-05-19 | — | — | WO | disclosed |
| US-4737511-A | Cardiotonic imidazolylphenylpyrrol-2-ones | SCHERING A.G. (DE) | 1988-04-12 | — | — | US | disclosed |