Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920336 | 0.82 | SLC6A4 (0.42) | SLC6A4MAPTMEN1KMT2A | |
| SCHEMBL731368 | 0.75 | ALDH1A1 (0.47) | SCD5ALDH1A1MAOAMAOB | |
| SCHEMBL1717026 | 0.75 | MAPT (0.59) | MAPTTSHRBRD4LMNAPDK1 | |
| SCHEMBL1972352 | 0.74 | SLC6A3 (0.45) | SLC6A4MAPT | |
| Hydrochloric Acid SCHEMBL731618 | 0.74 | ALDH1A1 (0.46) | SCD5ALDH1A1MAOAMAOBDRD2 | |
| SCHEMBL1970760 | 0.74 | SLC6A4 (0.47) | SLC6A4MAPTL3MBTL1HTTPDK1 | |
| SCHEMBL731968 | 0.73 | LMNA (0.42) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL1920169 | 0.71 | MC1R (0.47) | SLC6A4MEN1KMT2A | |
| SCHEMBL734281 | 0.71 | ALDH1A1 (0.46) | ALDH1A1MAOAMAOB | |
| SCHEMBL733359 | 0.71 | PDE10A (0.34) | MAPTBRD4L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138188-B2 | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines | PFIZER INC. (US) | 2012-03-20 | — | — | US | disclosed |