Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2307075 | 0.84 | LMNA (0.45) | LMNAHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1945899 | 0.82 | PDE10A (0.34) | HTTSMN1; SMN2 | |
| SCHEMBL733359 | 0.82 | PDE10A (0.34) | HTTSMN1; SMN2 | |
| SCHEMBL733746 | 0.82 | SMO (0.33) | — | |
| SCHEMBL1947125 | 0.81 | RXFP1 (0.39) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4242136 | 0.76 | LMNA (0.47) | LMNAHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2307986 | 0.75 | PANK3 (0.42) | LMNAHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2304480 | 0.75 | P2RX7 (0.38) | LMNAHTTKMT2AMEN1NOTUM | |
| SCHEMBL734283 | 0.73 | SCD5 (0.41) | LMNAHTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL731967 | 0.71 | KMT2A (0.51) | LMNAHTTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138188-B2 | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines | PFIZER INC. (US) | 2012-03-20 | — | — | US | disclosed |