Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 6/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL734002 | 0.99 | RAD52 (0.42) | RAD52OPRM1OGFRL1OPRL1OPRD1 | |
| SCHEMBL734526 | 0.85 | EGFR (0.47) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL734295 | 0.85 | KDM4E (0.47) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL734734 | 0.85 | ALDH1A1 (0.43) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL733625 | 0.85 | MTNR1A (0.48) | OPRM1OPRL1 | |
| SCHEMBL735878 | 0.84 | KDM4E (0.47) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL735512 | 0.84 | OPRM1 (0.44) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL735584 | 0.83 | KDM4E (0.46) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL734437 | 0.83 | OPRM1 (0.44) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL735043 | 0.82 | OPRM1 (0.45) | OPRM1OGFRL1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | RAD52 1699/4885OPRM1 1029/4885OGFRL1 4373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.