Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342790 | 0.93 | HSD11B1 (0.58) | HSD11B1MAPTPOLB | |
| SCHEMBL7336087 | 0.86 | HSD11B1 (0.52) | HSD11B1MAPTPOLBTP53MEN1 | |
| SCHEMBL7339659 | 0.85 | HSD11B1 (0.54) | HSD11B1MAPTPOLBTP53 | |
| SCHEMBL7341323 | 0.83 | HSD11B1 (0.49) | HSD11B1MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL7334097 | 0.83 | HSD11B1 (0.49) | HSD11B1MAPTALDH1A1POLBTP53 | |
| SCHEMBL7343733 | 0.82 | HSD11B1 (0.57) | HSD11B1MAPTALDH1A1POLBTP53 | |
| SCHEMBL7343828 | 0.81 | ALDH1A1 (0.52) | HSD11B1MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL7340189 | 0.81 | EDNRB (0.40) | HSD11B1ALDH1A1POLBKMT2A | |
| SCHEMBL7333608 | 0.81 | CHRM5 (0.42) | ALDH1A1POLBKMT2A | |
| SCHEMBL7334114 | 0.80 | HSD11B1 (0.46) | HSD11B1MAPTALDH1A1TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |