Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342790 | 0.89 | HSD11B1 (0.58) | HSD11B1POLBMAPTCA12CA9 | |
| SCHEMBL7336277 | 0.86 | HSD11B1 (0.48) | HSD11B1POLBMAPTTP53SMN1; SMN2 | |
| SCHEMBL7828653 | 0.85 | HSD11B1 (0.48) | HSD11B1POLBTSHRMAPTCA12 | |
| SCHEMBL7335669 | 0.85 | HSD11B1 (0.54) | HSD11B1POLBMAPTTP53 | |
| SCHEMBL7343733 | 0.82 | HSD11B1 (0.57) | HSD11B1POLBMAPTTP53 | |
| SCHEMBL6542769 | 0.82 | HSD11B1 (0.49) | HSD11B1POLBMAPTTP53SMN1; SMN2 | |
| SCHEMBL7336087 | 0.81 | HSD11B1 (0.52) | HSD11B1POLBMAPTTP53SMN1; SMN2 | |
| SCHEMBL7334097 | 0.80 | HSD11B1 (0.49) | HSD11B1POLBTSHRMAPTTP53 | |
| SCHEMBL6542054 | 0.80 | HSD11B1 (0.52) | HSD11B1POLBMAPTTP53 | |
| SCHEMBL7334969 | 0.80 | HSD11B1 (0.55) | HSD11B1POLBMAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | claimed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |