Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.55 |
| ▸ | PPARA | Q07869 | 7/20 | 0.55 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344016 | 1.00 | PPARG (0.55) | PPARGPPARAMMP12ALDH1A1TSHR | |
| SCHEMBL27886769 | 0.87 | MMP12 (0.47) | PPARGPPARAMMP12ACE | |
| SCHEMBL7495011 | 0.85 | PPARG (0.61) | PPARGPPARATSHRSRRACE | |
| SCHEMBL17515671 | 0.85 | MMP12 (0.49) | PPARGPPARAMMP12ALDH1A1TSHR | |
| SCHEMBL19486028 | 0.84 | MMP12 (0.48) | PPARGPPARAMMP12ALDH1A1TSHR | |
| SCHEMBL9397557 | 0.84 | SMN1; SMN2 (0.51) | PPARGPPARAMMP12ALDH1A1TSHR | |
| SCHEMBL2626716 | 0.82 | SRR (0.62) | PPARGPPARASRRACE | |
| SCHEMBL2729126 | 0.82 | PPARG (0.58) | PPARGPPARAMMP12TSHRSRR | |
| SCHEMBL1486321 | 0.82 | SRR (0.62) | PPARGPPARASRRACE | |
| SCHEMBL6628870 | 0.82 | PPARG (0.58) | PPARGPPARAMMP12TSHRSRR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258975-B1 | HYPOTENSIVE AGENTS | AJINOMOTO CO., INC. (JP) | 2001-07-10 | — | — | US | disclosed |
| US-6087526-A | Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester | AJINOMOTO CO., INC. (JP) | 2000-07-11 | — | — | US | disclosed |
| EP-0759424-B1 | Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester, and intermediate therefor | AJINOMOTO KK (JP) | 2000-06-14 | — | — | EP | disclosed |
| US-5959139-A | Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester | AJINOMOTO CO., INC. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0759424-A1 | Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester, and intermediate therefor | Ajinomoto Co., Inc. (JP) | 1997-02-26 | — | — | EP | disclosed |
| EP-0495822-A1 | CARBOXYALKYL DIPEPTIDE INHIBITORS OF ENDOPEPTIDASES | SCHERING CORPORATION (US) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991005796-A1 | CARBOXYALKYL DIPEPTIDE INHIBITORS OF ENDOPEPTIDASES | SCHERING CORPORATION (US) | 1991-05-02 | — | — | WO | disclosed |
| US-4782149-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVES | HOFFMAN-LA ROCHE INC. (US) | 1988-11-01 | — | — | US | disclosed |
| US-4757069-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1988-07-12 | — | — | US | disclosed |
| EP-0271795-A2 | Octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]diazepin derivatives, intermediates and process for their preparation, and medicament containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-06-22 | — | — | EP | disclosed |