Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRR | Q9GZT4 | 2/20 | 0.62 |
| ▸ | ACE | P12821 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 15/20 | 0.58 |
| ▸ | PPARA | Q07869 | 13/20 | 0.58 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2626716 | 1.00 | SRR (0.62) | SRRACEPPARGPPARAALPI | |
| SCHEMBL1486323 | 1.00 | SRR (0.62) | SRRACEPPARGPPARAALPI | |
| SCHEMBL2501988 | 0.93 | PPARG (0.65) | SRRACEPPARGPPARA | |
| SCHEMBL2501991 | 0.93 | PPARG (0.65) | SRRACEPPARGPPARA | |
| SCHEMBL2053 | 0.89 | SRR (0.53) | SRRACEPPARGPPARAALPI | |
| SCHEMBL5339462 | 0.87 | PPARG (0.71) | PPARGPPARAPTGS1 | |
| SCHEMBL5309440 | 0.87 | PPARG (0.71) | PPARGPPARAPTGS1 | |
| SCHEMBL5349209 | 0.86 | SRR (0.50) | SRRACEPPARGPPARAALPI | |
| SCHEMBL5349207 | 0.86 | SRR (0.50) | SRRACEPPARGPPARAALPI | |
| SCHEMBL5355644 | 0.86 | SRR (0.50) | SRRACEPPARGPPARAALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163943-B2 | Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing α-keto amide compound using them | SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2012-04-24 | — | — | US | disclosed |
| EP-1735332-B1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LAB (US) | 2011-10-19 | — | — | EP | disclosed |
| EP-2289887-A2 | Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them | SEIKAGAKU CORPORATION (JP) | 2011-03-02 | — | — | EP | disclosed |
| EP-2289888-A2 | Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them | SEIKAGAKU CORPORATION (JP) | 2011-03-02 | — | — | EP | disclosed |
| US-20080113982-A1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | ZHAO CHEN | 2008-05-15 | — | — | US | disclosed |
| US-20080113982-A1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | ZHAO CHEN | 2008-05-15 | — | — | US | disclosed |
| US-7345034-B2 | Azacyclosteroid histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345034-B2 | Azacyclosteroid histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2008-03-18 | — | — | US | disclosed |
| US-20080064873-A1 | Oxidizing an amino alcohol (obtained by ring opening the epoxy, aziding, reducing and reacting it with a carboxylic acid); stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | SEIKAGAKU KOGYO KABUSHIKI KAISHA D/B/A SEIKAGAKU CORPORATION (JP) | 2008-03-13 | — | — | US | disclosed |
| US-20080058516-A1 | Stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | SEIKAGAKU KOGYO KABUSHIKI KAISHA D/B/A SEIKAGAKU CORPORATION (JP) | 2008-03-06 | — | — | US | disclosed |
| EP-0481522-B1 | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-12-29 | — | — | EP | disclosed |
| EP-0729456-B1 | NOVEL PROCESS FOR PREPARING (S)-1-[2(S)-(1,3-DIHYDRO-1,3-DIOXO-ISOINDOL-2-YL)-1-OXO-3-PHENYLPROPYL]-1,2,3,4-TETRAHYDRO-2-PYRIDINE-CARBOXYLIC ACID METHYL ESTER AND INTERMEDIATES THEREOF | MERRELL PHARMA INC (US) | 1997-12-17 | — | — | EP | disclosed |
| EP-0729456-A1 | NOVEL PROCESS FOR PREPARING (S)-1-[2(S)-(1,3-DIHYDRO-1,3-DIOXO-ISOINDOL-2-YL)-1-OXO-3-PHENYLPROPYL]-1,2,3,4-TETRAHYDRO-2-PYRIDINE-CARBOXYLIC ACID METHYL ESTER AND INTERMEDIATES THEREOF | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5527795-A | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-18 | — | — | US | disclosed |
| US-5508411-A | Process for preparing (S)-1-[2(S)-(1,3-dihyrdro-1,3-dioxo-isoindo-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4,-tetrahydro-2-pyridine-carboxylic acid methyl ester | MERRELL PHARMACEUTICALS INC. | 1996-04-16 | — | — | US | disclosed |
| US-5502253-A | Cyclohex-2-enyl acetamides | MERRELL PHARMACEUTICALS INC. | 1996-03-26 | — | — | US | disclosed |
| US-5491143-A | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5430145-A | Analgesics, reduction of drug withdrawal symptoms, hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-04 | — | — | US | disclosed |
| WO-1995014663-A2 | NOVEL PROCESS FOR PREPARING (S)-1-[2(S)-(1,3-DIHYDRO-1,3-DIOXO-ISOINDO-2-YL)-1-OXO-3-PHENYLPROPYL]-1,2,3,4-TETRAHYDRO-2-PYRIDINE-CARBOXYLIC ACID METHYL ESTER AND INTERMEDIATES THEREOF | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| EP-0481522-A1 | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1992-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064873-A1 | Oxidizing an amino alcohol (obtained by ring opening the epoxy, aziding, reducing and reacting it with a carboxylic acid); stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | REN, CMA1, AKR1A1 | SRR 103/4885ACE 24/4885PPARG 3426/4885 |
| US-20080058516-A1 | Stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | CMA1, REN, TPSAB1 | SRR 116/4885ACE 7/4885PPARG 3888/4885 |
| US-20080113982-A1 | AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS | HRH4, HRH3, HRH2 | SRR 1971/4885ACE 1407/4885PPARG 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.