Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRR | Q9GZT4 | 2/20 | 0.62 |
| ▸ | ACE | P12821 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 15/20 | 0.58 |
| ▸ | PPARA | Q07869 | 13/20 | 0.58 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1486321 | 1.00 | SRR (0.62) | SRRACEPPARGPPARAALPI | |
| SCHEMBL1486323 | 1.00 | SRR (0.62) | SRRACEPPARGPPARAALPI | |
| SCHEMBL2501988 | 0.93 | PPARG (0.65) | SRRACEPPARGPPARA | |
| SCHEMBL2501991 | 0.93 | PPARG (0.65) | SRRACEPPARGPPARA | |
| SCHEMBL2053 | 0.89 | SRR (0.53) | SRRACEPPARGPPARAALPI | |
| SCHEMBL5339462 | 0.87 | PPARG (0.71) | PPARGPPARAPTGS1 | |
| SCHEMBL5309440 | 0.87 | PPARG (0.71) | PPARGPPARAPTGS1 | |
| SCHEMBL5349209 | 0.86 | SRR (0.50) | SRRACEPPARGPPARAALPI | |
| SCHEMBL5349207 | 0.86 | SRR (0.50) | SRRACEPPARGPPARAALPI | |
| SCHEMBL5355644 | 0.86 | SRR (0.50) | SRRACEPPARGPPARAALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220064170-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPUETICS INCORPORATED | 2022-03-03 | — | — | US | disclosed |
| US-20220064170-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPUETICS INCORPORATED | 2022-03-03 | — | — | US | disclosed |
| WO-2020123994-A1 | 2-((5-(PHENYL)-PYRROLO[2,1-F][1,2,4]TRIAZIN-4-YL)AMINO)-3-(PHENYL)PROPANOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS MCL-1 ENZYME INHIBITORS FOR TREATING CANCER | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2020-06-18 | — | — | WO | disclosed |
| WO-2020123994-A1 | 2-((5-(PHENYL)-PYRROLO[2,1-F][1,2,4]TRIAZIN-4-YL)AMINO)-3-(PHENYL)PROPANOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS MCL-1 ENZYME INHIBITORS FOR TREATING CANCER | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2020-06-18 | — | — | WO | disclosed |
| US-8785468-B2 | Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions | AMGEN INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785468-B2 | Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions | AMGEN INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120197015-A1 | EPOXYCARBOXAMIDE COMPOUND, AZIDE COMPOUND, AND AMINO ALCOHOL COMPOUND, AND PROCESS FOR PREPARING a-KETO AMIDE COMPOUND USING THEM | SEIKAGAKU KOGYO KABUSHIKI KAISHA D/B/A SEIKAGAKU CORPORATION (JP) | 2012-08-02 | — | — | US | disclosed |
| US-20120197015-A1 | EPOXYCARBOXAMIDE COMPOUND, AZIDE COMPOUND, AND AMINO ALCOHOL COMPOUND, AND PROCESS FOR PREPARING a-KETO AMIDE COMPOUND USING THEM | SEIKAGAKU KOGYO KABUSHIKI KAISHA D/B/A SEIKAGAKU CORPORATION (JP) | 2012-08-02 | — | — | US | disclosed |
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20080064873-A1 | Oxidizing an amino alcohol (obtained by ring opening the epoxy, aziding, reducing and reacting it with a carboxylic acid); stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | SEIKAGAKU KOGYO KABUSHIKI KAISHA D/B/A SEIKAGAKU CORPORATION (JP) | 2008-03-13 | — | — | US | disclosed |
| US-20080058516-A1 | Stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | SEIKAGAKU KOGYO KABUSHIKI KAISHA D/B/A SEIKAGAKU CORPORATION (JP) | 2008-03-06 | — | — | US | disclosed |
| US-20080058516-A1 | Stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | SEIKAGAKU KOGYO KABUSHIKI KAISHA D/B/A SEIKAGAKU CORPORATION (JP) | 2008-03-06 | — | — | US | disclosed |
| US-7326799-B2 | Oxidizing an amino alcohol (obtained by ring opening the epoxy, aziding, reducing and reacting it with a carboxylic acid); stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2008-02-05 | — | — | US | disclosed |
| US-7326799-B2 | Oxidizing an amino alcohol (obtained by ring opening the epoxy, aziding, reducing and reacting it with a carboxylic acid); stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2008-02-05 | — | — | US | disclosed |
| US-6531617-B2 | Adding an acid halide to a solution of aluminum chloride to form an alkylcarbonyloxy chromanone, which is further reacted with lithium (hydro)peroxide at a temperature of < 0 degrees C | MERCK & CO., INC. | 2003-03-11 | — | — | US | disclosed |
| US-20020095047-A1 | Process for preparing hydroxychomanones and CIS-aminochromanols | MERCK & CO., INC. | 2002-07-18 | — | — | US | disclosed |
| EP-0658169-A1 | DIAMINO ACID DERIVATIVES AS ANTIHYPERTENSIVES | SCHERING CORPORATION (US) | 1995-06-21 | — | — | EP | disclosed |
| US-5298492-A | Inhibitors of endopeptidase and treatment of cardiovascular disorders | SCHERING CORPORATION (US) | 1994-03-29 | — | — | US | disclosed |
| WO-1994003481-A1 | DIAMINO ACID DERIVATIVES AS ANTIHYPERTENSIVES | SCHERING CORPORATION (US) | 1994-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064873-A1 | Oxidizing an amino alcohol (obtained by ring opening the epoxy, aziding, reducing and reacting it with a carboxylic acid); stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | REN, CMA1, AKR1A1 | SRR 103/4885ACE 24/4885PPARG 3426/4885 |
| US-20120197015-A1 | EPOXYCARBOXAMIDE COMPOUND, AZIDE COMPOUND, AND AMINO ALCOHOL COMPOUND, AND PROCESS FOR PREPARING a-KETO AMIDE COMPOUND USING THEM | AKR1C1, AKR1C4, AADAC | SRR 527/4885ACE 1454/4885PPARG 3657/4885 |
| US-20220064170-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | CYP2C19, CYP2D6, CYP2C8 | SRR 2894/4885ACE 764/4885PPARG 1066/4885 |
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | IAPP, INSR, AMY2A | SRR 1048/4885ACE 1338/4885PPARG 233/4885 |
| US-20080058516-A1 | Stereoselectivity; protease inhibitors: antiallergens; anticarcinogenic and hypotensive agents | CMA1, REN, TPSAB1 | SRR 116/4885ACE 7/4885PPARG 3888/4885 |
| US-20020095047-A1 | Process for preparing hydroxychomanones and CIS-aminochromanols | HACL2, HAAO, APEH | SRR 1279/4885ACE 163/4885PPARG 3394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.