Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL751516 | 0.84 | HPGD (0.74) | CES1MEN1KMT2AMAPTHPGD | |
| SCHEMBL3633720 | 0.81 | CES2 (0.67) | CES1MEN1KMT2AMAPTHPGD | |
| SCHEMBL28972855 | 0.79 | KMT2A (0.65) | CES1MEN1KMT2AMAPTHPGD | |
| SCHEMBL649996 | 0.78 | CES2 (0.80) | CES1MEN1KMT2AMAPTHPGD | |
| SCHEMBL394576 | 0.76 | GSK3B (0.59) | CES1MEN1KMT2AMAPTHPGD | |
| SCHEMBL1305020 | 0.75 | GSK3B (0.70) | CES1MEN1KMT2AMAPTHPGD | |
| SCHEMBL11042754 | 0.75 | HPGD (0.47) | CES1MEN1KMT2AMAPTHPGD | |
| SCHEMBL2635792 | 0.74 | HAO1 (0.63) | CES1MEN1KMT2AMAPTHPGD | |
| SCHEMBL28387692 | 0.74 | CES2 (0.54) | CES1MEN1KMT2AMAPTHPGD | |
| Dibenzoylmethane SCHEMBL28139772 | 0.73 | KMT2A (0.85) | CES1MEN1KMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11208390-B2 | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions | THE GENERAL HOSPITAL CORPORATION (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200199085-A1 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS | THE GENERAL HOSPITAL CORPORATION | 2020-06-25 | — | — | US | disclosed |
| US-10611738-B2 | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions | THE GENERAL HOSPITAL CORPORATION (US) | 2020-04-07 | — | — | US | disclosed |
| US-20190040021-A1 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS | THE GENERAL HOSPITAL CORPORATION | 2019-02-07 | — | — | US | disclosed |
| US-9902705-B2 | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions | THE GENERAL HOSPITAL CORPORATION (US) | 2018-02-27 | — | — | US | disclosed |
| US-20150246893-A1 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS | THE GENERAL HOSPITAL CORPORATION (US) | 2015-09-03 | — | — | US | disclosed |
| US-8138226-B2 | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity | AUSPEX PHARMACEUTICALS (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090023765-A1 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
| US-20090018207-A1 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| EP-1315492-A2 | A METHOD FOR TREATING ALLERGIES USING SUBSTITUTED PYRAZOLES | Ortho McNeil Pharmaceutical, Inc. (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-1309593-A2 | SUBSTITUTED PYRAZOLES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-1268478-A2 | PHENYL-SUBSTITUTED IMIDAZOPYRIDINES | Ortho McNeil Pharmaceutical, Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2002020013-A2 | A METHOD FOR TREATING ALLERGIES USING SUBSTITUTED PYRAZOLES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-14 | — | — | WO | disclosed |
| WO-2002014315-A2 | SUBSTITUTED PYRAZOLES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-02-21 | — | — | WO | disclosed |
| WO-2001074815-A2 | PHENYL-SUBSTITUTED IMIDAZOPYRIDINES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | disclosed |
| WO-1999055664-A1 | PREPARATION OF CARBOCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199085-A1 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS | TIE1, TTL, EPHA2 | CES1 2680/4885MEN1 2588/4885KMT2A 3412/4885 |
| US-11208390-B2 | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions | TIE1, TTL, EPHA2 | CES1 2680/4885MEN1 2588/4885KMT2A 3412/4885 |
| US-20090018207-A1 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY | SLC6A4, HTR4, GPR34 | CES1 1473/4885MEN1 757/4885KMT2A 4413/4885 |
| US-20150246893-A1 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS | TIE1, TTL, EPHA2 | CES1 2680/4885MEN1 2588/4885KMT2A 3412/4885 |
| US-10611738-B2 | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions | TIE1, TTL, EPHA2 | CES1 2680/4885MEN1 2588/4885KMT2A 3412/4885 |
| US-20090023765-A1 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY | SLC6A4, HTR4, GPR34 | CES1 1473/4885MEN1 757/4885KMT2A 4413/4885 |
| US-20190040021-A1 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS | TIE1, TTL, EPHA2 | CES1 2680/4885MEN1 2588/4885KMT2A 3412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.