Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559196 | 0.77 | THRB (0.55) | THRBKCNJ5KCNJ3 | |
| SCHEMBL8710430 | 0.77 | AVPR2 (0.67) | AVPR1A | |
| SCHEMBL7344295 | 0.76 | KCNQ2 (0.47) | THRBKCNQ2KCNJ5KCNJ3AVPR1A | |
| SCHEMBL8561675 | 0.74 | NAMPT (0.50) | THRBKCNQ2KCNJ5KCNJ3ALDH1A1 | |
| SCHEMBL8556372 | 0.73 | KCNJ5 (0.51) | THRBKCNQ2KCNJ5KCNJ3AVPR1A | |
| SCHEMBL7340964 | 0.73 | KCNJ5 (0.48) | THRBKCNQ2KCNJ5KCNJ3 | |
| SCHEMBL8557995 | 0.72 | KCNJ5 (0.47) | THRBKCNQ2KCNJ5KCNJ3AVPR1A | |
| SCHEMBL8563252 | 0.71 | TP53 (0.47) | THRBKCNQ2KCNJ5KCNJ3MAPT | |
| SCHEMBL8564493 | 0.71 | KCNJ5 (0.46) | THRBKCNQ2KCNJ5KCNJ3MAPT | |
| SCHEMBL7344569 | 0.70 | AVPR2 (0.65) | AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5244898-A | Vasopressin antagonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0514667-A1 | Benzazepin derivatives as vasopressin antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-25 | — | — | EP | disclosed |