Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 4/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4620598 | 0.90 | HCAR2 (0.37) | HCAR2KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL2646503 | 0.79 | MEN1 (0.38) | HCAR2KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL6759519 | 0.78 | HCAR2 (0.36) | HCAR2KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL8680389 | 0.77 | HCAR2 (0.34) | HCAR2KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL24228647 | 0.76 | HCAR2 (0.35) | HCAR2KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL24228671 | 0.76 | TNF (0.35) | HCAR2KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL7950768 | 0.73 | ALDH1A1 (0.39) | HCAR2KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL7977219 | 0.73 | CRBN (0.38) | HCAR2ALDH1A1KDM4EHSD17B10USP2 | |
| SCHEMBL8060250 | 0.73 | FFAR3 (0.33) | ALDH1A1 | |
| SCHEMBL13072044 | 0.71 | ALDH1A1 (0.34) | ALDH1A1KDM4EMAPTHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658211-B2 | Polyconjugates for in vivo delivery of polynucleotides | Arrowhead Madison Inc. (US) | 2014-02-25 | — | — | US | disclosed |
| US-8658211-B2 | Polyconjugates for in vivo delivery of polynucleotides | Arrowhead Madison Inc. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20120230938-A1 | Polyconjugates for In Vivo Delivery of Polynucleotides | Arrowhead Madison Inc. (US) | 2012-09-13 | — | — | US | disclosed |
| US-8137695-B2 | Transferring interfering RNA sequences into cells via conjugation with physiologically labile bond associated with polyamine and/or polyvinyl ether | Arrowhead Madison Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138383-B2 | For cellular delivery; heterogeneity polymer containing cationic groups and hydrophobic groups | Arrowhead Madison Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8017109-B2 | Cellular deivery, random polyacrylate with multiple hydrophobic monomer | ROCHE MADISON INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-8008355-B2 | Delivering nucleic acids to cells; copolymer containing amine monomer and hydrophobic segments | ROCHE MADISON INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-7985406-B2 | For cellular delivery; heteropolymer containing amine containing monomer and hydrophobic monomers | ROCHE MADISON INC. (US) | 2011-07-26 | — | — | US | disclosed |
| US-20090048410-A1 | Membrane Active Heteropolymers | Arrowhead Pharmaceuticals, Inc. | 2009-02-19 | — | — | US | disclosed |
| US-20090023890-A1 | Membrane Active Heteropolymers | Arrowhead Pharmaceuticals, Inc. | 2009-01-22 | — | — | US | disclosed |
| US-20080287630-A1 | Endosomolytic Poly(Acrylate) Polymers | Arrowhead Pharmaceuticals, Inc. | 2008-11-20 | — | — | US | disclosed |
| US-20080287628-A1 | Endosomolytic Poly(Vinyl Ether) Polymers | Arrowhead Madison Inc. | 2008-11-20 | — | — | US | disclosed |
| US-20080281044-A1 | Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers | ROCHE MADISON INC. | 2008-11-13 | — | — | US | disclosed |
| US-20080281041-A1 | Reverse deactivation of membrane active polymers; cell delivery; labile bonding of polyamines, polyvinyl alcohol, polyallylamine or polyoxyethylene glycol | Arrowhead Madison Inc. | 2008-11-13 | — | — | US | disclosed |
| US-20080269450-A1 | Endosomolytic Poly-Beta-Aminoester Polymers | ROCHE MADISON INC. | 2008-10-30 | — | — | US | disclosed |
| US-20080152661-A1 | Polyconjugates for In Vivo Delivery of Polynucleotides | Arrowhead Pharmaceuticals, Inc. | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120230938-A1 | Polyconjugates for In Vivo Delivery of Polynucleotides | PHAX, NCL, PCBP1 | HCAR2 3649/4885KMT2A 4050/4885ALDH1A1 4805/4885 |
| US-20080152661-A1 | Polyconjugates for In Vivo Delivery of Polynucleotides | PHAX, PCBP1, NCL | HCAR2 3573/4885KMT2A 4125/4885ALDH1A1 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.