Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | MELK | Q14680 | 4/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.38 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341800 | 0.75 | PTGS2 (0.61) | PTGS2PTGS1CXCL8AKR1B10UGT1A9 | |
| SCHEMBL6277797 | 0.75 | GAA (0.60) | PTGS2PTGS1CXCL8AKR1B10UGT1A9 | |
| SCHEMBL9195674 | 0.74 | ALOX5 (0.47) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6261264 | 0.74 | KMT2A (0.42) | PTGS2PTGS1HDAC6CXCL8AKR1B10 | |
| Acetic Acid SCHEMBL457990 | 0.74 | CXCL8 (0.51) | PTGS2PTGS1HDAC6CXCL8AKR1B10 | |
| SCHEMBL10439813 | 0.74 | HDAC6 (0.42) | PTGS2PTGS1HDAC6CXCL8AKR1B10 | |
| Acetic Acid SCHEMBL9525251 | 0.73 | CAMK2A (0.50) | PTGS2PTGS1HDAC6CXCL8AKR1B10 | |
| SCHEMBL25183896 | 0.73 | NR1H4 (0.46) | PTGS2PTGS1ALOX5NR1H4AKR1C3 | |
| Acetic Acid SCHEMBL4029469 | 0.73 | CXCL8 (0.50) | PTGS2PTGS1HDAC6CXCL8AKR1B10 | |
| Acetic Acid SCHEMBL30628161 | 0.73 | CXCL8 (0.50) | PTGS2PTGS1HDAC6CXCL8AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112846-A | Nonsteroidal antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1992-05-12 | — | — | US | disclosed |
| US-5075330-A | N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents | WARNER-LAMBERT CO. (US) | 1991-12-24 | — | — | US | disclosed |
| US-4981865-A | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents | WARNER-LAMBERT CO. (US) | 1991-01-01 | — | — | US | disclosed |