Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | MYC | P01106 | 2/20 | 0.50 |
| ▸ | MAX | P61244 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10884175 | 0.81 | RAB9A (0.64) | MAPTSMN1; SMN2TP53GAANPC1 | |
| SCHEMBL7302748 | 0.79 | MAPT (0.58) | MAPTSMN1; SMN2TP53GAANPC1 | |
| SCHEMBL9803090 | 0.75 | GAA (0.61) | GAARAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL5182877 | 0.75 | GAA (0.58) | SMN1; SMN2TP53GAANPC1RAB9A | |
| SCHEMBL5184066 | 0.74 | NPC1 (0.54) | SMN1; SMN2GAANPC1RAB9AKDM4E | |
| SCHEMBL10886311 | 0.74 | LMNA (0.52) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL20932779 | 0.73 | ALDH1A1 (0.59) | MAPTSMN1; SMN2TP53GAANPC1 | |
| SCHEMBL27594605 | 0.73 | PDE5A (0.51) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL10885726 | 0.72 | RAB9A (0.64) | MAPTSMN1; SMN2TP53GAANPC1 | |
| SCHEMBL7341049 | 0.72 | MAPK14 (0.43) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582506-B1 | Tetrahydronaphtalene derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1996-02-28 | — | — | EP | disclosed |
| US-5373023-A | Antiischaemic agent | SYNTHELABO (FR) | 1994-12-13 | — | — | US | disclosed |
| EP-0582506-A1 | Tetrahydronaphtalene derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1994-02-09 | — | — | EP | disclosed |