Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | MGAM | O43451 | 3/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.34 |
| ▸ | SI | P14410 | 3/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9994966 | 0.85 | FAAH (0.40) | GRM2ALDH1A1L3MBTL1 | |
| SCHEMBL7350749 | 0.76 | ASAH1 (0.38) | MEN1KMT2AALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9982902 | 0.73 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1 | |
| SCHEMBL7346527 | 0.73 | L3MBTL1 (0.39) | MEN1KMT2AALDH1A1L3MBTL1MTNR1A | |
| SCHEMBL459733 | 0.71 | GAA (0.60) | F12GAAMGAMAMY1ASI | |
| SCHEMBL476712 | 0.70 | GRM2 (0.54) | GRM2 | |
| SCHEMBL9736525 | 0.70 | MEN1 (0.43) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL7352544 | 0.69 | SYK (0.35) | MEN1KMT2AASAH1MTNR1AMTNR1B | |
| SCHEMBL3865262 | 0.66 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2ASAH1 | |
| SCHEMBL1162095 | 0.65 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1ASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |