Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.63 |
| ▸ | DRD3 | P35462 | 5/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 6/20 | 0.58 |
| ▸ | DRD5 | P21918 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7347501 | 0.99 | DRD2 (0.62) | DRD2DRD3KCNH2HTR1ADRD5 | |
| SCHEMBL7068893 | 0.97 | KCNH2 (0.64) | DRD2DRD3KCNH2HTR1ADRD5 | |
| SCHEMBL7346970 | 0.83 | KCNH2 (0.67) | DRD2DRD3KCNH2HTR1AHTR7 | |
| SCHEMBL9299310 | 0.81 | DRD2 (0.54) | DRD2DRD3KCNH2HTR1ASIGMAR1 | |
| SCHEMBL5988317 | 0.81 | KCNH2 (0.88) | DRD2DRD3KCNH2HTR1ACYP2D6 | |
| SCHEMBL7344989 | 0.81 | HTR1A (0.64) | DRD2DRD3HTR1ADRD5CYP2D6 | |
| SCHEMBL6924599 | 0.81 | ADRA1A (0.57) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL6924603 | 0.80 | DRD3 (0.55) | DRD2DRD3HTR1AHTR7 | |
| SCHEMBL8143460 | 0.80 | HTR1A (0.61) | DRD2HTR1AHTR2A | |
| SCHEMBL7935881 | 0.79 | DRD2 (0.61) | DRD2DRD3KCNH2HTR2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281594-A | Dopamine antagonist, Parkinson's disease and drug addiction | THE UPJOHN COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | disclosed |