Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.35 |
| ▸ | ITGAV | P06756 | 4/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.35 |
| ▸ | MDM4 | O15151 | 3/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343247 | 0.91 | EPHX2 (0.36) | SMN1; SMN2F10PRSS1EPHX2MEN1 | |
| SCHEMBL7345104 | 0.88 | ITGB3 (0.34) | SMN1; SMN2ITGB3ITGA2BHTTL3MBTL1 | |
| SCHEMBL7343256 | 0.79 | KMT2A (0.37) | SMN1; SMN2ITGB3ITGAVEPHX2MEN1 | |
| SCHEMBL6773153 | 0.76 | ITGB3 (0.55) | SMN1; SMN2ITGB3ITGA2BHTTL3MBTL1 | |
| SCHEMBL7340450 | 0.76 | HTT (0.37) | SMN1; SMN2ITGB3ITGA2BHTTL3MBTL1 | |
| SCHEMBL6366986 | 0.74 | PLA2G10 (0.47) | SMN1; SMN2ITGB3ITGA2BHTTL3MBTL1 | |
| SCHEMBL27502754 | 0.74 | ITGB3 (0.47) | SMN1; SMN2ITGB3ITGA2BHTTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6773326 | 0.73 | PLA2G10 (0.46) | SMN1; SMN2ITGB3ITGA2BHTTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6368863 | 0.73 | PLA2G10 (0.46) | SMN1; SMN2ITGB3ITGA2BHTTL3MBTL1 | |
| SCHEMBL7348597 | 0.73 | ITGB3 (0.38) | SMN1; SMN2ITGB3ITGA2BHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |