Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345104 | 0.91 | ITGB3 (0.34) | KMT2AMEN1SMN1; SMN2MITFLMNA | |
| SCHEMBL7343247 | 0.87 | EPHX2 (0.36) | KMT2AMEN1SMN1; SMN2MITFLMNA | |
| SCHEMBL7345087 | 0.79 | SMN1; SMN2 (0.38) | KMT2AMEN1SMN1; SMN2EPHX2ITGB3 | |
| SCHEMBL6779680 | 0.72 | GPR139 (0.45) | KMT2AMEN1MAPK1GPR139ITGB3 | |
| SCHEMBL7340566 | 0.71 | PTPRC (0.33) | KMT2AMEN1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL7341130 | 0.69 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2GPR139ITGB3 | |
| SCHEMBL7344227 | 0.69 | HTT (0.40) | KMT2AMEN1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL7341076 | 0.69 | SMN1; SMN2 (0.36) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL27502755 | 0.69 | ITGB3 (0.41) | KMT2ASMN1; SMN2LMNAKDM4EEPHX2 | |
| SCHEMBL7341582 | 0.68 | GPR139 (0.41) | KMT2AMEN1ALDH1A1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |