Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345087 | 0.91 | SMN1; SMN2 (0.38) | EPHX2SMN1; SMN2F10PRSS1MEN1 | |
| SCHEMBL7343256 | 0.87 | KMT2A (0.37) | EPHX2MITFLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7345104 | 0.78 | ITGB3 (0.34) | MITFLMNASMN1; SMN2F10PRSS1 | |
| SCHEMBL6779650 | 0.72 | GPR139 (0.43) | ALDH1A1F2MEN1KMT2ARAB9A | |
| SCHEMBL7339143 | 0.71 | RXFP1 (0.48) | SMN1; SMN2F10ALDH1A1PRSS1MEN1 | |
| SCHEMBL7372871 | 0.70 | PLK4 (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7340450 | 0.70 | HTT (0.37) | EPHX2LMNASMN1; SMN2F10ALDH1A1 | |
| SCHEMBL7340563 | 0.70 | RXFP1 (0.35) | EPHX2SMN1; SMN2F10ALDH1A1PRSS1 | |
| SCHEMBL7832432 | 0.69 | GAA (0.47) | SMN1; SMN2F10ALDH1A1PRSS1MEN1 | |
| SCHEMBL7341050 | 0.69 | ALDH1A1 (0.37) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |