SCHEMBL7345142

SCHEMBL7345142

CC(C)(C)OC(=O)NCCCCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NC(=O)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.43
SUCNR1 Q9BXA5 8/20 0.43
HDAC1 Q13547 4/20 0.41
HDAC8 Q9BY41 4/20 0.41
HDAC3 O15379 2/20 0.41
HDAC4 P56524 2/20 0.41
HDAC2 Q92769 2/20 0.41
HDAC10 Q969S8 2/20 0.41
HDAC11 Q96DB2 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
HDAC9 Q9UKV0 2/20 0.41
HDAC5 Q9UQL6 2/20 0.41
SIRT5 Q9NXA8 1/20 0.41
MAPT P10636 1/20 0.40
ITGB3 P05106 1/20 0.40
ITGAV P06756 1/20 0.40
ITGA2B P08514 1/20 0.40
ITGB5 P18084 1/20 0.40
ITGB6 P18564 1/20 0.40
HDAC7 Q8WUI4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7349358 0.86 ITGB3 (0.41) SUCNR1MAPTITGB3ITGAV
SCHEMBL7355053 0.86 ITGB3 (0.41) SUCNR1MAPTITGB3ITGAV
SCHEMBL7352151 0.83 ITGB3 (0.44) HDAC1HDAC8HDAC3HDAC4HDAC2
SCHEMBL7355857 0.81 ITGB3 (0.45) HDAC1HDAC8HDAC3HDAC4HDAC2
SCHEMBL26222687 0.76 MAPT (0.52) CYP3A4MAPT
SCHEMBL9295145 0.74 CTSK (0.41)
SCHEMBL9295158 0.74 ITGB3 (0.43) HDAC1HDAC8HDAC3HDAC4HDAC2
SCHEMBL16495064 0.73 MEN1 (0.52) CYP3A4HDAC1HDAC8
SCHEMBL14598333 0.73 CTSS (0.57)
SCHEMBL5131178 0.72 SMN1; SMN2 (0.66) CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0570507-A4 ANTI-AGGREGATORY PEPTIDES CONTAINING AN AROMATIC ESTER OR AMIDE SMITHKLINE BEECHAM CORP (US) 1994-09-21 EP disclosed
EP-0570507-A1 ANTI-AGGREGATORY PEPTIDES CONTAINING AN AROMATIC ESTER OR AMIDE SMITHKLINE BEECHAM CORPORATION (US) 1993-11-24 EP disclosed
WO-1992013552-A1 ANTI-AGGREGATORY PEPTIDES CONTAINING AN AROMATIC ESTER OR AMIDE SMITHKLINE BEECHAM CORPORATION (US) 1992-08-20 WO disclosed