SCHEMBL7345166

SCHEMBL7345166

O=C(Nc1ccc(C(=O)N2Cc3cccnc3Oc3ccccc32)cn1)c1ccccc1Cl

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7334471 0.91 TP53 (0.44) TP53MAPT
SCHEMBL7334422 0.90 TP53 (0.41) TP53MAPT
SCHEMBL7334278 0.90 AVPR2 (0.43)
SCHEMBL7343236 0.90 AVPR2 (0.45)
SCHEMBL7345315 0.89 TP53 (0.40) TP53MAPT
SCHEMBL7340863 0.88 CHRNB2 (0.46)
SCHEMBL7342685 0.88 TP53 (0.40) TP53MAPT
SCHEMBL7336084 0.88 TP53 (0.41) TP53MAPT
SCHEMBL7335173 0.87 LMNA (0.40) TP53MAPT
SCHEMBL7342280 0.87 MEN1 (0.47) TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996022282-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1996-07-25 WO disclosed