Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489275 | 0.82 | ALDH1A1 (0.58) | KDM4EGAAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL22645269 | 0.81 | ALDH1A1 (0.44) | KDM4EGAAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8724484 | 0.80 | GAA (0.45) | KDM4EGAAALDH1A1MGAMSI | |
| SCHEMBL23041374 | 0.73 | DGKA (0.41) | KDM4EGAAALDH1A1MGAMSI | |
| SCHEMBL5179848 | 0.73 | GAA (0.40) | KDM4EGAAALDH1A1MGAMSI | |
| SCHEMBL2701579 | 0.72 | GAA (0.60) | GAAALDH1A1MGAMSIMGAM2 | |
| SCHEMBL9742574 | 0.71 | ALDH1A1 (0.41) | KDM4EGAAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7340478 | 0.71 | HSD17B10 (0.60) | GAAALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL22882677 | 0.71 | MGAM (0.43) | GAAALDH1A1MGAMSIMGAM2 | |
| Water SCHEMBL2703341 | 0.70 | GAA (0.57) | GAAALDH1A1MGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |