Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.48 |
| ▸ | GPR139 | Q6DWJ6 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.38 |
| ▸ | ITGAV | P06756 | 5/20 | 0.38 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.37 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336179 | 0.82 | SMN1; SMN2 (0.41) | GPR139MEN1KMT2AATMITGB3 | |
| SCHEMBL7347348 | 0.80 | KMT2A (0.38) | ITGB1ITGA5GPR139MEN1KMT2A | |
| SCHEMBL7345600 | 0.80 | NPC1 (0.39) | MEN1KMT2AITGB3ITGAVITGB6 | |
| SCHEMBL7338744 | 0.80 | LMNA (0.46) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7343848 | 0.79 | SMN1; SMN2 (0.38) | ITGB1ITGA5MEN1KMT2AITGB3 | |
| SCHEMBL7343852 | 0.79 | SMN1; SMN2 (0.38) | ITGB1ITGA5MEN1KMT2AITGB3 | |
| SCHEMBL6778158 | 0.78 | ITGB3 (0.48) | ITGB1ITGA5GPR139MEN1KMT2A | |
| SCHEMBL7823048 | 0.78 | ITGB3 (0.48) | ITGB1ITGA5GPR139MEN1KMT2A | |
| SCHEMBL7343935 | 0.77 | ALDH1A1 (0.41) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7349856 | 0.76 | ITGB3 (0.46) | ITGB1ITGA5MEN1KMT2AITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |