Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | GOT1 | P17174 | 4/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | SNCA | P37840 | 6/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.69 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.66 |
| ▸ | MMP9 | P14780 | 1/20 | 0.64 |
| ▸ | MMP8 | P22894 | 1/20 | 0.64 |
| ▸ | MMP14 | P50281 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23925504 | 0.93 | GOT1 (0.78) | MAPTSMN1; SMN2POLBGOT1MEN1 | |
| SCHEMBL23925548 | 0.92 | TSHR (0.68) | MAPTSMN1; SMN2POLBGOT1MEN1 | |
| SCHEMBL23925476 | 0.86 | MAPT (0.76) | MAPTSMN1; SMN2POLBGOT1MEN1 | |
| SCHEMBL26430630 | 0.86 | MAPT (0.76) | MAPTSMN1; SMN2POLBGOT1MEN1 | |
| SCHEMBL734585 | 0.85 | MEN1 (1.00) | MAPTSMN1; SMN2POLBGOT1MEN1 | |
| SCHEMBL23925499 | 0.84 | MAPT (0.68) | MAPTSMN1; SMN2POLBGOT1MEN1 | |
| SCHEMBL9939452 | 0.82 | SNCA (1.00) | MEN1KMT2ASNCAPTGS1PTGS2 | |
| SCHEMBL892597 | 0.82 | MMP9 (0.79) | SMN1; SMN2SNCATSHRPTGS1PTGS2 | |
| SCHEMBL15313111 | 0.81 | SNCA (1.00) | MAPTSNCAPTGS1PTGS2 | |
| SCHEMBL18229449 | 0.81 | LMNA (0.57) | MAPTSMN1; SMN2SNCAPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC | 2023-04-27 | — | — | US | claimed |
| WO-2021211123-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2021-10-21 | — | — | WO | claimed |
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC | 2023-04-27 | — | — | US | disclosed |
| WO-2021211123-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2021-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | TLR4, TLR5, TLR1 | MAPT 1718/4885SMN1; SMN2 4580/4885POLB 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.