Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 2/20 | 0.55 |
| ▸ | CPA3 | P15088 | 2/20 | 0.55 |
| ▸ | CPB1 | P15086 | 1/20 | 0.55 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.44 |
| ▸ | LAP3 | P28838 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346272 | 1.00 | CPA1 (0.55) | CPA1CPA3CPB1CPB2LTA4H | |
| SCHEMBL7289839 | 0.91 | CPA3 (0.66) | CPA1CPA3CPB1CPB2LTA4H | |
| SCHEMBL8399603 | 0.91 | CPA3 (0.66) | CPA1CPA3CPB1CPB2LTA4H | |
| SCHEMBL7354310 | 0.91 | CPA3 (0.66) | CPA1CPA3CPB1CPB2LTA4H | |
| SCHEMBL3701204 | 0.87 | CPA1 (0.57) | CPA1CPA3CPB1CPB2LTA4H | |
| SCHEMBL2571746 | 0.83 | CPA1 (0.56) | CPA1CPA3CPB1CPB2SLC15A1 | |
| SCHEMBL21811160 | 0.80 | CYP1A2 (0.59) | CPA1CPA3CPB1CPB2LTA4H | |
| SCHEMBL22064243 | 0.79 | ALDH1A1 (0.49) | LTA4HLAP3ALDH1A1CTRB1 | |
| SCHEMBL38661393 | 0.79 | ALDH1A1 (0.49) | LTA4HLAP3ALDH1A1CTRB1 | |
| SCHEMBL22783732 | 0.79 | SLC7A5 (0.53) | LTA4HSLC15A1LAP3ALDH1A1CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5442044-A | Hypotensive agents | PFIZER INC. (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0661292-A1 | Orally active renin inhibitors | PFIZER INC. (US) | 1995-07-05 | — | — | EP | disclosed |
| EP-0438233-A2 | Orally active renin inhibitors | PFIZER INC. (US) | 1991-07-24 | — | — | EP | disclosed |