Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.34 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | CTSG | P08311 | 1/20 | 0.30 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353733 | 0.82 | MAOB (0.43) | MAOAMAOBSTK17B | |
| SCHEMBL7347199 | 0.81 | MAOB (0.33) | MAOAMAOBSTK17B | |
| SCHEMBL6426238 | 0.81 | KCNA3 (0.37) | TXNRD1TXNRD3TXNRD2MAOAMAOB | |
| SCHEMBL7346833 | 0.81 | MAOB (0.37) | MRGPRX4MAOAMAOBSTK17B | |
| SCHEMBL6422310 | 0.79 | MTNR1A (0.36) | TXNRD1TXNRD3TXNRD2MAOAMAOB | |
| SCHEMBL7347057 | 0.75 | STK17B (0.33) | STK17B | |
| SCHEMBL6820565 | 0.75 | KCNA3 (0.36) | MAOAMAOBSTK17B | |
| SCHEMBL7347047 | 0.73 | MCHR1 (0.47) | KCNH2 | |
| SCHEMBL6823437 | 0.71 | TSHR (0.41) | — | |
| SCHEMBL6820552 | 0.70 | STK17B (0.35) | MAOAMAOBSTK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| EP-1026165-A1 | O-substituted Hydroxycoumaranone derivatives as antitumor and antimetastatic agents | Roche Diagnostics GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |