Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 12/20 | 0.55 |
| ▸ | MMP2 | P08253 | 11/20 | 0.53 |
| ▸ | MMP1 | P03956 | 11/20 | 0.53 |
| ▸ | MMP13 | P45452 | 11/20 | 0.53 |
| ▸ | MMP3 | P08254 | 9/20 | 0.53 |
| ▸ | MMP7 | P09237 | 8/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | NAT1 | P18440 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349158 | 0.91 | MMP2 (0.51) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7758584 | 0.91 | MMP2 (0.51) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7758579 | 0.91 | MMP2 (0.51) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7354064 | 0.89 | MMP9 (0.69) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7354161 | 0.87 | MMP13 (0.56) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7763645 | 0.87 | MMP9 (0.55) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7348920 | 0.87 | MMP9 (0.55) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL6272434 | 0.81 | MMP13 (0.71) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL8776693 | 0.79 | MMP2 (0.60) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL12520517 | 0.79 | MMP2 (0.60) | MMP9MMP2MMP1MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973748-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5985900-A | TREATING TUMOR GROWTH, INVASION OR METASTASIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CHRONIC DERMAL WOUNDS, CORNEAL ULCERATION, DEGENERATIVE SKIN DISORDERS, MULTIPLE SCLEROSIS, STROKE, ATHEROSCLEROSIS, | AGOURON PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1998043963-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-10-08 | — | — | WO | disclosed |