Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 6/20 | 0.55 |
| ▸ | MMP2 | P08253 | 6/20 | 0.53 |
| ▸ | MMP1 | P03956 | 5/20 | 0.53 |
| ▸ | MMP13 | P45452 | 4/20 | 0.53 |
| ▸ | MMP3 | P08254 | 3/20 | 0.53 |
| ▸ | MMP7 | P09237 | 3/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348920 | 1.00 | MMP9 (0.55) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7378977 | 0.91 | PGR (0.51) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7354064 | 0.89 | MMP9 (0.69) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7355956 | 0.88 | MMP9 (0.48) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL6264449 | 0.87 | MMP1 (0.61) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7347207 | 0.87 | MMP9 (0.55) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7354161 | 0.87 | MMP13 (0.56) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL6270601 | 0.86 | MMP9 (0.46) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL6270025 | 0.84 | MMP9 (0.45) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL7351765 | 0.83 | MMP9 (0.80) | MMP9MMP2MMP1MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | claimed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | claimed |
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |