Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PNLIP | P16233 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197356 | 0.84 | SGMS2 (0.42) | NR3C1BRD4TP53SMN1; SMN2MAPT | |
| SCHEMBL7353383 | 0.74 | LMNA (0.49) | TP53MAPTMEN1KMT2ALMNA | |
| SCHEMBL3029893 | 0.73 | MAPT (0.50) | TP53MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7163100 | 0.73 | MAPT (0.58) | BRD4MAPTMEN1KMT2ALMNA | |
| SCHEMBL7003270 | 0.73 | TERT (0.48) | NR3C1BRD4TP53SMN1; SMN2MAPT | |
| SCHEMBL6197039 | 0.73 | KMT2A (0.53) | SMN1; SMN2MEN1KMT2ALMNAPDE5A | |
| SCHEMBL1669 | 0.71 | TERT (0.64) | NR3C1BRD4TP53SMN1; SMN2MAPT | |
| SCHEMBL7167278 | 0.71 | MAPT (0.53) | BRD4MAPTMEN1KMT2ALMNA | |
| SCHEMBL7718074 | 0.71 | BRD4 (0.55) | BRD4TP53MAPTMEN1KMT2A | |
| SCHEMBL7721826 | 0.70 | PTPN1 (0.58) | BRD4MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| WO-1993007149-A1 | PYRAZOLOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1993-04-15 | — | — | WO | disclosed |