Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.45 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.45 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.45 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347337 | 1.00 | KMT2A (0.47) | KMT2AKDM4ELMNAABCC9ABCC8 | |
| SCHEMBL8775041 | 1.00 | KMT2A (0.47) | KMT2AKDM4ELMNAABCC9ABCC8 | |
| SCHEMBL7347332 | 1.00 | KMT2A (0.47) | KMT2AKDM4ELMNAABCC9ABCC8 | |
| SCHEMBL7423086 | 0.88 | HSD17B10 (0.40) | KMT2AABCC9KCNJ11MEN1HTT | |
| SCHEMBL7347341 | 0.87 | ADRB2 (0.42) | KMT2AKDM4ELMNAABCC9ABCC8 | |
| SCHEMBL11165563 | 0.86 | LMNA (0.50) | KMT2ALMNAABCC9ABCC8KCNJ11 | |
| SCHEMBL7352521 | 0.85 | ABCC9 (0.39) | KMT2AKDM4ELMNAABCC9ABCC8 | |
| SCHEMBL8774741 | 0.85 | ABCC9 (0.39) | KMT2AKDM4ELMNAABCC9ABCC8 | |
| SCHEMBL7356810 | 0.85 | KMT2A (0.47) | KMT2AKDM4ELMNAABCC9ABCC8 | |
| SCHEMBL4258463 | 0.85 | KMT2A (0.47) | KMT2AKDM4ELMNAABCC9ABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655057-B1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | UPJOHN CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5567722-A | DIURETICS | THE UPJOHN COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004499-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |
| WO-1994004500-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |