Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 10/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 10/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 7/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347332 | 0.87 | KMT2A (0.47) | ABCC9KCNJ11ABCC8KCNJ8KMT2A | |
| SCHEMBL8775041 | 0.87 | KMT2A (0.47) | ABCC9KCNJ11ABCC8KCNJ8KMT2A | |
| SCHEMBL7347337 | 0.87 | KMT2A (0.47) | ABCC9KCNJ11ABCC8KCNJ8KMT2A | |
| SCHEMBL7347329 | 0.87 | KMT2A (0.47) | ABCC9KCNJ11ABCC8KCNJ8KMT2A | |
| SCHEMBL8774741 | 0.85 | ABCC9 (0.39) | ABCC9KCNJ11ABCC8KCNJ8KMT2A | |
| SCHEMBL7352521 | 0.85 | ABCC9 (0.39) | ABCC9KCNJ11ABCC8KCNJ8KMT2A | |
| SCHEMBL11165563 | 0.80 | LMNA (0.50) | ABCC9KCNJ11ABCC8KCNJ8KMT2A | |
| SCHEMBL7347346 | 0.79 | ABCC9 (0.50) | ADRB2ADRB1ADRB3ABCC9KCNJ11 | |
| SCHEMBL9434671 | 0.77 | ABCC9 (0.42) | ABCC9KCNJ11ABCC8KCNJ8KMT2A | |
| SCHEMBL11160950 | 0.76 | ABCC9 (0.51) | ABCC9KCNJ11ABCC8KCNJ8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655057-B1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | UPJOHN CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5567722-A | DIURETICS | THE UPJOHN COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| WO-1994004500-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |