Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.53 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | CCR3 | P51677 | 6/20 | 0.50 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353904 | 0.94 | MCHR1 (0.55) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 | |
| SCHEMBL7350951 | 0.93 | DRD4 (0.47) | MCHR1SLC6A12TMEM97SIGMAR1SSTR5 | |
| SCHEMBL7347675 | 0.90 | UTS2R (0.49) | MCHR1SLC6A12TMEM97SSTR5ACKR3 | |
| SCHEMBL7347703 | 0.88 | MCHR1 (0.49) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 | |
| SCHEMBL7347047 | 0.88 | MCHR1 (0.47) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 | |
| SCHEMBL7346972 | 0.87 | SLC6A5 (0.60) | SIGMAR1HTR2AMEN1KMT2ADRD2 | |
| SCHEMBL7346827 | 0.86 | SSTR5 (0.47) | MCHR1SLC6A12TMEM97SSTR5MEN1 | |
| SCHEMBL6466592 | 0.85 | HTR7 (0.55) | MCHR1SLC6A12TMEM97SIGMAR1HTR2A | |
| SCHEMBL6458101 | 0.84 | HTR7 (0.54) | MCHR1SLC6A12TMEM97SIGMAR1HTR2A | |
| SCHEMBL6462598 | 0.84 | HTR7 (0.54) | MCHR1SLC6A12TMEM97SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | claimed |
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| EP-1026165-A1 | O-substituted Hydroxycoumaranone derivatives as antitumor and antimetastatic agents | Roche Diagnostics GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |