Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.49 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353904 | 0.90 | MCHR1 (0.55) | MCHR1SLC6A12TMEM97SIGMAR1SSTR5 | |
| SCHEMBL7347047 | 0.88 | MCHR1 (0.47) | MCHR1SLC6A12TMEM97SIGMAR1HTR1A | |
| SCHEMBL7347684 | 0.88 | MCHR1 (0.53) | MCHR1SLC6A12TMEM97SIGMAR1SSTR5 | |
| SCHEMBL6466592 | 0.85 | HTR7 (0.55) | MCHR1SLC6A12TMEM97SIGMAR1HTR1A | |
| SCHEMBL6462598 | 0.85 | HTR7 (0.54) | MCHR1SLC6A12TMEM97SIGMAR1HTR1A | |
| SCHEMBL6458101 | 0.85 | HTR7 (0.54) | MCHR1SLC6A12TMEM97SIGMAR1HTR1A | |
| SCHEMBL7352709 | 0.83 | HTR7 (0.45) | MCHR1SLC6A12TMEM97SIGMAR1HTR1A | |
| SCHEMBL7347807 | 0.83 | HTR7 (0.53) | MCHR1SLC6A12TMEM97SIGMAR1HTR1A | |
| SCHEMBL6457221 | 0.83 | HTR7 (0.55) | MCHR1SLC6A12TMEM97SIGMAR1HTR1A | |
| SCHEMBL7346972 | 0.83 | SLC6A5 (0.60) | SIGMAR1HTR2ADRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | claimed |
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| EP-1026165-A1 | O-substituted Hydroxycoumaranone derivatives as antitumor and antimetastatic agents | Roche Diagnostics GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |