Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342545 | 0.90 | PSMB5 (0.47) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7342540 | 0.90 | PSMB5 (0.47) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7346557 | 0.89 | CTSG (0.48) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7346551 | 0.89 | CTSG (0.48) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7301731 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7301741 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7301724 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7312135 | 0.84 | CTSG (0.46) | SMN1; SMN2PSMB5PSMB1PSMB2CTSG | |
| SCHEMBL7312126 | 0.84 | CTSG (0.46) | SMN1; SMN2PSMB5PSMB1PSMB2CTSG | |
| SCHEMBL7300779 | 0.84 | REN (0.51) | PSMB5PSMB1PSMB2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603873-B1 | Aminoketone derivatives | MITSUBISHI CHEM CORP (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5424325-A | Inibitors of thiol protease and may be used as therapeutic agents for treating muscular dystrophy, cataracts, strokes | MITSUBISHI KASEI CORPORATION (JP) | 1995-06-13 | — | — | US | disclosed |
| EP-0603873-A1 | Aminoketone derivatives | Mitsubishi Chemical Corporation (JP) | 1994-06-29 | — | — | EP | disclosed |