SCHEMBL7348456

SCHEMBL7348456

COC(=O)C1=C(C)NC(C)=C(C(=O)OCCC2NCc3ccccc32)C1c1cnc2ccccc2c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.43
CACNA1C Q13936 2/20 0.41
CACNA1F O60840 1/20 0.41
CACNA1D Q01668 1/20 0.41
CACNA1S Q13698 1/20 0.41
LNPEP Q9UIQ6 1/20 0.40
PDE1C Q14123 3/20 0.39
LMNA P02545 2/20 0.38
CYP1A2 P05177 2/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2D6 P10635 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
NPC1 O15118 1/20 0.38
ABCC4 O15439 1/20 0.38
ABCB11 O95342 1/20 0.38
PGR P06401 1/20 0.38
CHRM2 P08172 1/20 0.38
ABCB1 P08183 1/20 0.38
HTR1A P08908 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7347767 0.83 CACNA1B (0.49) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7348450 0.82 ADORA3 (0.56) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7349305 0.81 CACNA1B (0.54) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7348446 0.81 ADORA3 (0.46) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7345505 0.81 POLB (0.55) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7343716 0.81 CACNA1B (0.49) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7341786 0.81 CACNA1C (0.59) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7344608 0.81 KDM4E (0.62) ADORA3LMNACYP1A2CYP3A4CYP2D6
SCHEMBL7344616 0.80 CACNA1B (0.49) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7348034 0.80 CACNA1C (0.46) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4833150-A HYPOTENSIVES, ANTIARRHYTHMIA AGENTS NELSON RESEARCH & DEVELOPMENT CO. (US) 1989-05-23 US disclosed
US-4652573-A HYPOTENSIVE AGENTS NELSON RESEARCH & DEVELOPMENT CO. (US) 1987-03-24 US disclosed
EP-0194685-A1 1,4-Dihydropyridines Whitby Research Incorporated (US) 1986-09-17 EP disclosed