Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304270 | 0.84 | KCNN4 (0.43) | KMT2AMAPTCYP2C19NR3C2KCNN4 | |
| SCHEMBL7301814 | 0.80 | KMT2A (0.40) | KMT2AMAPTHSD11B1ALDH1A1F2 | |
| SCHEMBL21393560 | 0.73 | ALDH1A1 (0.38) | MAPTALDH1A1NPC1 | |
| SCHEMBL4401320 | 0.70 | CA1 (0.50) | KMT2AMAPTNR3C2ALDH1A1MEN1 | |
| SCHEMBL7315311 | 0.70 | MAPT (0.43) | KMT2AMAPTCYP2C19HIF1AHSD11B1 | |
| SCHEMBL28376940 | 0.70 | MAPT (0.55) | KMT2AMAPTCYP2C19NR3C2KCNN4 | |
| SCHEMBL28710857 | 0.67 | MAPT (0.52) | KMT2AMAPTCYP2C19KCNN4HIF1A | |
| SCHEMBL168185 | 0.67 | MAPT (0.44) | KMT2AMAPTCYP2C19NR3C2HIF1A | |
| SCHEMBL4557719 | 0.67 | CYP2C19 (0.43) | CYP2C19HSD11B1CYP1A2MAPK1 | |
| SCHEMBL5674843 | 0.67 | MAPT (0.52) | KMT2AMAPTCYP2C19NR3C2KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931788-B1 | Metalloprotease inhibitors | PFIZER LTD (GB) | 2002-11-06 | — | — | EP | disclosed |
| US-6090852-A | MATRIX METALLOPROTEASE INHIBITOR | PFIZER INC (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0931788-A2 | Metalloprotease inhibitors | Pfizer Limited (GB) | 1999-07-28 | — | — | EP | disclosed |